“The biggest sporting event in the world is going to attract a bigger handle than it has before.” “It's a very safe bet to say that this will be the most bet upon soccer event in American betting history,” says Casey Clark, the senior vice president at the AGA. Men’s National Team in the tournament once again, this year is expected to be the most wagered on World Cup in U.S. are expected to bet $1.8 billion on the 2022 World Cup, according to a study published by the American Gaming Association. An estimated 20.5 million adults in the U.S.